daratumumab

Ligand id: 7395

Name: daratumumab

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Daratumumab is reported to induce complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity (ADCC) in patient-derived multiple myeloma cells [2].
Peptide sequence analysis of the heavy chain variable region of daratumumab matches a sequence claimed in patent US7829673 [1], and is the heavy chain component of monoclonal −005 described therein.
Selectivity at human other protein targets
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Target Type Action Affinity Units Concentration range (M) Reference
CD38 Antibody Antagonist 8.2 pKd - 1
pKd 8.2 (Kd 6.06x10-9 M) [1]