vedolizumab

Ligand id: 7437

Name: vedolizumab

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Bioactivity Comments
In vitro, vedolizumab inhibits specific binding of α4β7 +ve lymphoma cells to immobilised MADCAM1 or fibronectin with IC50 values of 0.39nM and 0.14nM respectively [2]. Soler et al. (2009) also show by FACS analysis that vedolizumab binds specifically to cells exogenously expressing the α4 and β7 intergrin proteins [2].
Selectivity at human catalytic receptors
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Target Type Action Affinity Units Concentration range (M) Reference
integrin α4β7 Antibody Antagonist 8.3 pIC50 - 1
pIC50 8.3 (IC50 5.34x10-9 M) [1]
Description: Binding to HuT-78 cells