vedolizumab

Ligand id: 7437

Name: vedolizumab

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View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
In vitro, vedolizumab inhibits specific binding of α4β7 +ve lymphoma cells to immobilised MADCAM1 or fibronectin with IC50 values of 0.39nM and 0.14nM respectively [2]. Soler et al. (2009) also show by FACS analysis that vedolizumab binds specifically to cells exogenously expressing the α4 and β7 intergrin proteins [2].
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
integrin α4β7 Hs Antibody Antagonist 8.3 pIC50 - 1
pIC50 8.3 (IC50 5.34x10-9 M) [1]
Description: Binding to HuT-78 cells