Ligand id: 7474

Name: difluprednate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 106.97
Molecular weight 508.23
XLogP 2.64
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Difluprednate has a reported Ki of 0.78nM [1] in a glucocorticoid receptor binding assay. As it is clear from the structure of this drug that it is a glucocorticoid receptor agonist we have tagged this receptor as the primary drug target, despite being unable to identify publicly available bioactivity data at the human glucocorticoid receptor.
Selectivity at nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Glucocorticoid receptor Hs Agonist Agonist - - - 1