difluprednate

Ligand id: 7474

Name: difluprednate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 106.97
Molecular weight 508.23
XLogP 2.64
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Approved to treat eye pain and inflammation following opthalmic surgery and to treat anterior uveitis.
Mechanism Of Action and Pharmacodynamic Effects
Difluprednate acst to activate the glucocorticoid receptor. Glucocorticoid receptor agonists modulate the expression of genes containing the glucocorticoid response element (GRE). Although complex, the response appears to include inhibition of the biosynthesis of pro-inflammatory prostaglandins and leukotrienes.
External links