olaparib

Ligand id: 7519

Name: olaparib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 69.72
Molecular weight 434.18
XLogP 3.39
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
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Target Type Action Affinity Units Concentration range (M) Reference
poly(ADP-ribose) polymerase 2 Inhibitor Inhibition 9.0 pIC50 - 3,5
pIC50 9.0 (IC50 1x10-9 M) [3,5]
Description: Assayed using PARP-2 isolated from HeLa cells, in a scintillation proximity ELISA.
poly(ADP-ribose) polymerase 1 Inhibitor Inhibition 8.3 pIC50 - 3,5
pIC50 8.3 (IC50 5x10-9 M) [3,5]
Description: Assayed using PARP-1 isolated from HeLa cells, in a scintillation proximity ELISA.