olaparib

Ligand id: 7519

Name: olaparib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 69.72
Molecular weight 434.18
XLogP 3.39
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (EMA & FDA (2014))
IUPAC Name
4-[[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one
International Nonproprietary Names
INN number INN
8685 olaparib
Synonyms
AZD-2281 | AZD2281 | Lynparza®
Database Links
CAS Registry No. 763113-22-0
ChEMBL Ligand CHEMBL521686
GtoPdb PubChem SID 187051821
PubChem CID 23725625
RCSB PDB Ligand 09L
Search Google for chemical match using the InChIKey FDLYAMZZIXQODN-UHFFFAOYSA-N
Search Google for chemicals with the same backbone FDLYAMZZIXQODN
Search PubMed clinical trials olaparib
Search PubMed titles olaparib
Search PubMed titles/abstracts olaparib
Search UniChem for chemical match using the InChIKey FDLYAMZZIXQODN-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone FDLYAMZZIXQODN
SynPHARM 79917 (in complex with poly(ADP-ribose) polymerase 1)
79918 (in complex with poly(ADP-ribose) polymerase 2)
Wikipedia Olaparib
Comments
Olaparib is an AstraZeneca poly ADP ribose polymerase (PARP) inhibitor [5]. It is discussed in the AZ 2014 review paper [2].