Compound class:
Synthetic organic
Comment: This is an investigational Alzheimer's disease (AD) compound. Chemically, it is a hybrid of curcumin and melatonin [1], two compounds which have previously shown some benefit in AD research. The hybrid molecule is brain-penetrant. In in vitro experiments, compound 7 exhibits significant neuroprotective activity in AD model cells [1]. The ChemSpider ID is 30922431.
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Bioactivity Comments |
In MC65 cells (a cellular model of AD derived from transformed human neuroblastoma cells) treated with compound 7, a neuroprotective effect is observed with an EC50 value of approximately 28nM [1]. |