compound 7 [PMID: 24825313]

Ligand id: 7531

Name: compound 7 [PMID: 24825313]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 10
Topological polar surface area 91.42
Molecular weight 380.17
XLogP 3.1
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Bioactivity Comments
In MC65 cells (a cellular model of AD derived from transformed human neuroblastoma cells) treated with compound 7, a neuroprotective effect is observed with an EC50 value of approximately 28nM [1].