Compound class:
Synthetic organic
Comment: This is an investigational Alzheimer's disease (AD) compound. Chemically, it is a hybrid of curcumin and melatonin [1], two compounds which have previously shown some benefit in AD research. The hybrid molecule is brain-penetrant. In in vitro experiments, compound 7 exhibits significant neuroprotective activity in AD model cells [1]. The ChemSpider ID is 30922431.
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No information available. |
Mechanism Of Action and Pharmacodynamic Effects |
The precise molecular mechanism of action causative of the neuroprotective effect of this compound is unresolved, but may be associated with its antioxidant properties [1], rather than a being a direct effect on Aβ levels or Aβ oligomer formation. |