citalopram

Ligand id: 7547

Name: citalopram

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View more information in the IUPHAR Pharmacology Education Project: citalopram

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 36.26
Molecular weight 324.16
XLogP 3.96
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human transporters
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
SERT Inhibitor Inhibition 8.4 pKi - 1
pKi 8.4 (Ki 4.38x10-9 M) [1]
Description: Displacement of [3H]citalopram from human SERT expressed in HEK293 cells.
NET Inhibitor Inhibition <3.0 pKi - 2
pKi <3.0 (Ki >1x10-3 M) [2]
Description: Inhibition of [3H]dopamine uptake at human NET expressed in COS7 cells.