Ligand id: 7547

Name: citalopram

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 36.26
Molecular weight 324.16
XLogP 3.96
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to improve symptoms of depression and anxiety in patients with major depressive disorder, panic disorder, generalized anxiety disorder or social phobia and reduce compulsive behaviour and obsessional thoughts in patients with obsessive compulsive disorder (OCD).
Mechanism Of Action and Pharmacodynamic Effects
Citalopram is a selective serotonin reuptake inhibitor (SSRI). SSRIs increase serotonin levels at post-synaptic sites by inhibiting the pre-synaptic transporter (SLC6A4) normally involved in its re-uptake. This enhances serotonergic neurotransmission with the clinical outcomes being improved mood and decreased anxiety.
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