Ligand id: 7554

Name: dexmethylphenidate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 38.33
Molecular weight 233.14
XLogP 4.21
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
DAT Hs Inhibitor Inhibition 7.6 pKi - 2
pKi 7.6 (Ki 2.5x10-8 M) [2]
Description: Displacement of [3H]WIN-35428 from human DAT stably expressed in mouse N2A cells
NET Rn Inhibitor Inhibition 6.6 pKi - 1
pKi 6.6 (Ki 2.7x10-7 M) [1]
Description: Displacement of [3H]nisoxetine from NET in Sprague-Dawley rat cortical tissue.