dexmethylphenidate

Ligand id: 7554

Name: dexmethylphenidate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 38.33
Molecular weight 233.14
XLogP 4.22
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human transporters
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
DAT Inhibitor Inhibition 7.6 pKi - 2
pKi 7.6 (Ki 2.5x10-8 M) [2]
Description: Displacement of [3H]WIN-35428 from human DAT stably expressed in mouse N2A cells
Selectivity at rat transporters
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
NET Inhibitor Inhibition 6.6 pKi - 1
pKi 6.6 (Ki 2.7x10-7 M) [1]
Description: Displacement of [3H]nisoxetine from NET in Sprague-Dawley rat cortical tissue.