Ligand id: 7558

Name: tianeptine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 95.09
Molecular weight 436.12
XLogP 4.15
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
In electrophysiology experiments using mouse hippocampal slices, 100 μM tianeptine increases the amplitude of isolated AMPA receptor mediated fEPSPs (field excitatory post-synaptic potentials) by approximately 163% after 60 min administration [6]. As there appears to be no publicly available bioactivity data for this drug at its human molecular target(s) we have not mapped a primary drug target in this instance.