tianeptine

Ligand id: 7558

Name: tianeptine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 95.09
Molecular weight 436.12
XLogP 4.15
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Brink CB, Harvey BH, Brand L. (2006)
Tianeptine: a novel atypical antidepressant that may provide new insights into the biomolecular basis of depression.
Recent Pat CNS Drug Discov1 (1): 29-41. [PMID:18221189]
2. Kasper S, McEwen BS. (2008)
Neurobiological and clinical effects of the antidepressant tianeptine.
CNS Drugs22 (1): 15-26. [PMID:18072812]
3. McEwen BS, Chattarji S. (2004)
Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptine.
Eur Neuropsychopharmacol14 Suppl 5: S497-502. [PMID:15550348]
4. McEwen BS, Chattarji S, Diamond DM, Jay TM, Reagan LP, Svenningsson P, Fuchs E. (2010)
The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation.
Mol. Psychiatry15 (3): 237-49. [PMID:19704408]
5. Svenningsson P, Bateup H, Qi H, Takamiya K, Huganir RL, Spedding M, Roth BL, McEwen BS, Greengard P. (2007)
Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine.
Eur. J. Neurosci.26 (12): 3509-17. [PMID:18088278]
6. Szegedi V, Juhász G, Zhang X, Barkóczi B, Qi H, Madeira A, Kapus G, Svenningsson P, Spedding M, Penke B. (2011)
Tianeptine potentiates AMPA receptors by activating CaMKII and PKA via the p38, p42/44 MAPK and JNK pathways.
Neurochem. Int.59 (8): 1109-22. [PMID:22056552]