BX 471

Ligand id: 767

Name: BX 471

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 87.9
Molecular weight 434.15
XLogP 2.47
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
BX 471 exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
CCR1 Hs Antagonist Antagonist 8.2 – 9.0 pKi - 3
pKi 8.2 – 9.0 (Ki 6.31x10-9 – 1x10-9 M) [3]