BX 471

Ligand id: 767

Name: BX 471

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 87.9
Molecular weight 434.15
XLogP 2.47
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Anders HJ, Vielhauer V, Frink M, Linde Y, Cohen CD, Blattner SM, Kretzler M, Strutz F, Mack M, Gröne HJ et al.. (2002)
A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation.
J. Clin. Invest., 109 (2): 251-9. [PMID:11805137]
2. Furuichi K, Gao JL, Horuk R, Wada T, Kaneko S, Murphy PM. (2008)
Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury.
J. Immunol., 181 (12): 8670-6. [PMID:19050287]
3. Liang M, Mallari C, Rosser M, Ng HP, May K, Monahan S, Bauman JG, Islam I, Ghannam A, Buckman B, Shaw K, Wei GP, Xu W, Zhao Z, Ho E, Shen J, Oanh H, Subramanyam B, Vergona R, Taub D, Dunning L, Harvey S, Snider RM, Hesselgesser J, Morrissey MM, Perez HD. (2000)
Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1.
J Biol Chem, 275: 19000-19008. [PMID:10748002]