Ligand id: 7714

Name: AZD8055

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 93.07
Molecular weight 465.24
XLogP 2.19
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
AZD8055 inhibitory effect (IC50) of the transcriptional complexes mTORC1 and mTORC2 are reported as 27nM and 24nM respectively [5]. mTORC1 acts as a nutrient/energy/redox sensor and controls protein synthesis and has been related to ageing in experiments using model organisms [3-4,6]. mTORC2 regulates cellular metabolism and the cytoskeleton [7] and may play a role in the regulation of autophagy [2,8].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
mechanistic target of rapamycin kinase Hs Inhibitor Inhibition 9.1 pIC50 - 5
pIC50 9.1 (IC50 8x10-10 M) [5]