compound 23n [PMID: 24900877]

Ligand id: 7832

Name: compound 23n [PMID: 24900877]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 78.87
Molecular weight 512.27
XLogP 10.05
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Compound 23n caused weight loss, reduced liver triglycerides and depleted serum triglycerides following lipid challenge in mouse studies [1].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
diacylglycerol O-acyltransferase 1 Hs Inhibitor Inhibition 7.2 pIC50 - 1
pIC50 7.2 (IC50 6.4x10-8 M) [1]