Ligand id: 7875

Name: copanlisib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 127.43
Molecular weight 480.22
XLogP 0.22
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Copanlisib inhibits PI3Kα-dependent phosphorylation of Akt with an IC50 of 0.4-0.6 nM in KPL4 cells [1]. In LPA stimulated PC3 cells, the IC50 for PI3Kβ-dependent Akt phosphorylation was 7.8-10 nM [1].