Ligand id: 7875

Name: copanlisib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 127.43
Molecular weight 480.22
XLogP 0.22
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Liu N, Rowley BR, Bull CO, Schneider C, Haegebarth A, Schatz CA, Fracasso PR, Wilkie DP, Hentemann M, Wilhelm SM et al.. (2013)
BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models.
Mol. Cancer Ther., 12 (11): 2319-30. [PMID:24170767]
2. No authors listed. (2014)
Preliminary results of a phase II study of single agent Bay 80-6946, a Novel PI3K inhibitor, in patients with relapsed/refractory, indolent or aggressive lymphoma.
Clin Adv Hematol Oncol, 12 (2 Suppl 5): 14-6. [PMID:24852792]