Ligand id: 7899

Name: cyclopenthiazide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 135.12
Molecular weight 379.04
XLogP 1.43
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Cyclopenthiazide alters sodium and chloride transport in the distal renal tubule in dogs [1] where it is believed to inhibit activity of the thiazide-sensitive Na-Cl symporter NCC (SLC12A3), in a manner similar to other thiazide diuretics. However, we have been unable to find any publicly available bioactivity data supporting NCC as this drug's molecular target.