Ligand id: 7899

Name: cyclopenthiazide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 135.12
Molecular weight 379.04
XLogP 1.43
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Cyclopenthiazide acts as a diuretic.
This drug is not approved by the US FDA. In the UK it is approved as a component of the fixed-dose medication Navispare® which also contains amiloride (in use since 2006) hydrochloride. Other national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Thiazide diuretics block the active reabsorption of chloride in the ascending loop of Henle by inhibiting the thiazide-sensitive sodium-chloride symporter, SLC12A3. This results in excretion of sodium, chloride and water, thus reducing fluid retention and oedema.
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