capmatinib

Ligand id: 7904

Name: capmatinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 85.07
Molecular weight 412.14
XLogP 3.83
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
In vitro capmatinib (INCB28060) inhibits c-MET activation and signaling in cancer cells whose growth is driven by the c-MET activated pathway [1], and releases cells from c-MET-induced resistance to apoptosis. In vivo, capmatinib potently inhibits tumour growth in c-MET-dependent mouse models [1].
Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
MET proto-oncogene, receptor tyrosine kinase Inhibitor Inhibition 9.9 pIC50 - 1
pIC50 9.9 (IC50 1.3x10-10 M) [1]