Ligand id: 7914

Name: BV-6

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 18
Hydrogen bond donors 8
Rotatable bonds 37
Topological polar surface area 239.28
Molecular weight 1204.74
XLogP 15.89
No. Lipinski's rules broken 4

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human other protein targets
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
X-linked inhibitor of apoptosis Inhibitor Inhibition 8.9 pKd - 1
pKd 8.9 (Kd 1.3x10-9 M) [1]
Description: Assayed using expressed XIAP BIR2-BIR3 domain construct
baculoviral IAP repeat containing 2 Inhibitor Inhibition 6.3 – 7.5 pKd - 1
pKd 6.3 – 7.5 (Kd 4.6x10-7 – 2.9x10-8 M) [1]
Description: Assayed using expressed cIAP1 BIR2-BIR3 domain construct