Ligand id: 8069

Name: CP-673451

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 78.43
Molecular weight 417.22
XLogP 3.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
CP-673451 has antiangiogenic and antitumour activity in vivo [1]. Inhibitory activity at PDGFRα is 10-fold less than for PDGFRβ [1]. The related receptor tyrosine kinase c-Kit is an off-target of this compound.
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
platelet derived growth factor receptor beta Hs Inhibitor Inhibition 9.0 pIC50 - 1
pIC50 9.0 (IC50 1x10-9 M) [1]
platelet derived growth factor receptor alpha Hs Inhibitor Inhibition 8.0 pIC50 - 1
pIC50 8.0 (IC50 1x10-8 M) [1]
KIT proto-oncogene receptor tyrosine kinase Hs Inhibitor Inhibition 6.6 pIC50 - 1
pIC50 6.6 (IC50 2.52x10-7 M) [1]