compound 26 [PMID: 24673130]

Ligand id: 8134

Name: compound 26 [PMID: 24673130]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 64.69
Molecular weight 240.08
XLogP 2.65
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Off-targets include PI4Kβ (phosphatidylinositol 4-kinase, catalytic, beta) and MINK1 (misshapen-like kinase 1) [1].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
mitogen-activated protein kinase kinase kinase kinase 4 Hs Inhibitor Inhibition 7.8 pIC50 - 1
pIC50 7.8 (IC50 1.7x10-8 M) [1]