compound 14 [PMID: 24900428]

Ligand id: 8154

Name: compound 14 [PMID: 24900428]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 76.24
Molecular weight 381.15
XLogP 2.87
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Compound 14 is reported to be selective for CK1γ compared to CK1δ and CK1α [1].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
casein kinase 1 gamma 2 Inhibitor Inhibition 8.5 pIC50 - 1
pIC50 8.5 (IC50 3x10-9 M) [1]
casein kinase 1 delta Inhibitor Inhibition 7.2 pIC50 - 1
pIC50 7.2 (IC50 5.9x10-8 M) [1]
casein kinase 1 alpha 1 Inhibitor Inhibition 6.3 pIC50 - 1
pIC50 6.3 (IC50 4.42x10-7 M) [1]