compound 13 [PMID: 15925511]

Ligand id: 8188

Name: compound 13 [PMID: 15925511]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 119.56
Molecular weight 388.03
XLogP 5.63
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Although compound shows favourable actvity against SRPK1 it is not selective, inhibiting additional kinases such as Src, Kit, PDGFRβ, c-Met and Lck [1].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
SRSF protein kinase 1 Hs Inhibitor Inhibition 7.4 pIC50 - 1
pIC50 7.4 (IC50 4x10-8 M) [1]