Compound class:
Synthetic organic
Comment: Compound 6e is potent and selective endothelin receptor (ETA) antagonist. It has therapeutic potential in cardiovascular diseases [1].
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Bioactivity Comments |
Compound 6e is a nM selective endothelin receptor (ETA) antagonist. The compound effectively relieves rat hypoxia-induced pulmonary arterial hypertension and right ventricular weight ratio [1]. |