Compound class:
Synthetic organic
Comment: Compound 6e is potent and selective endothelin receptor (ETA) antagonist. It has therapeutic potential in cardiovascular diseases [1].
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References |
1. Cai J, Liu L, Hong KH, Wang P, Li L, Cao M, Sun C, Wu X, Zong X, Chen J et al.. (2015)
Discovery of phenoxybutanoic acid derivatives as potent endothelin antagonists with antihypertensive activity. Bioorg Med Chem, 23 (4): 657-67. [PMID:25614116] |