cmp5 [PMID: 25742700]

Ligand id: 8288

Name: cmp5 [PMID: 25742700]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 29.85
Molecular weight 315.17
XLogP 4.71
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Bioactivity Comments
Inhibition of PRMT5 by cmp5 is reported to restore regulatory checkpoints in lymphoma cells, thereby repressing B lymphocyte transformation [1].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
protein arginine methyltransferase 5 Inhibitor Inhibition - - - 1
[1]