safinamide

Ligand id: 8291

Name: safinamide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 64.35
Molecular weight 302.14
XLogP 3.07
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Safinamide is >800-fold selective for MAOB over MAOA [2].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Monoamine oxidase B Inhibitor Inhibition 6.3 pKi - 1
pKi 6.3 (Ki 4.5x10-7 M) [1]
Monoamine oxidase B Inhibitor Inhibition 8.1 pIC50 - 4
pIC50 8.1 (IC50 7.7x10-9 M) [4]