(-)-englerin A

Ligand id: 8372

Name: (-)-englerin A

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 82.06
Molecular weight 442.24
XLogP 6.65
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Bioactivity Comments
Englerin A is reported to selectively inhibit renal cancer cell growth [4] in vitro with a reported IC50 of 45nM against A498 kidney cancer cells [3].
Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPC4 Agonist Agonist - - - 1
[1]
TRPC5 Agonist Agonist - - - 1
[1]