Ligand id: 8423

Name: pimavanserin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 44.81
Molecular weight 427.26
XLogP 5.03
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Pimavanserin is approximately 40-fold selective for 5-HT2A receptors compared to 5-HT2B receptors [1].
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
5-HT2A receptor Hs Antagonist Inverse agonist 9.3 pKi - 2-3
pKi 9.3 [2-3]
Description: Ki determined in membrane radioligand binding assay.