Ligand id: 8474

Name: AZD8330

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 90.9
Molecular weight 461.02
XLogP 2.82
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Thre is no peer reviewed efficacy data available for this compound. An IC50 value of 7nM was presented in a meeting abstract at the AACR Annual Meeting in 2009 Abstract #3696: AZD8330 (ARRY-424704): Preclinical evaluation of a potent, selective MEK 1/2 inhibitor currently in phase I trials)