Ligand id: 8547

Name: CYM2503

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 12
Hydrogen bond donors 5
Rotatable bonds 20
Topological polar surface area 163.96
Molecular weight 765.41
XLogP 9.98
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
CYM2503 potentiates the anticonvulsant activity of endogenous galanin in rodent models of epilepsy [1].
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
GAL2 receptor Rn Allosteric modulator Positive 9.2 pEC50 - 1
pEC50 9.2 (EC50 6.9x10-10 M) [1]
Description: Potentiation of galanin-induced IP1 accumulation in vitro.