compound 14 [PMID: 23634668]

Ligand id: 8557

Name: compound 14 [PMID: 23634668]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 91.32
Molecular weight 480.23
XLogP 5.96
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
This compound retains its inhibitory activity against METAP1 in the presence of Co, but loses inhibitory activity against METAP1 in the presence of Mn2+.
Compound 14 does not inhibit methionyl aminopeptidase 2 (METAP2) [1].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Methionyl aminopeptidase 1 Inhibitor Inhibition 7.0 pEC50 - 1
pEC50 7.0 (EC50 9.3x10-8 M) [1]
Description: In the presence of Co.