Ligand id: 8695

Name: evofosfamide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 121.13
Molecular weight 446.93
XLogP 1.5
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
TH-302 potently inhibits cell proliferation in vitro, with an IC50 value of 19nM under hypoxic conditions, and 5100nM under normoxic conditions [2]. This shows that TH-302 is 270 times more active in hypoxic compared to normoxic conditions. Preclinical data is reported in [4].