Ligand id: 8806

Name: A1P

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 107.16
Molecular weight 198.11
XLogP -3.15
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
A1P attenuates airways hyperresponsiveness in a murine model of allergic airways inflammation [1].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Arginase I Hs Inhibitor Inhibition 5.7 pKd - 1
pKd 5.7 (Kd 2x10-6 M) [1]
Description: Dissociation constant measured using surface plasmon resonance assay.
Arginase I Hs Inhibitor Inhibition 5.4 pKi - 1
pKi 5.4 (Ki 4x10-6 M) [1]
Description: Measured using an enzyme kinetics assay.