compound 5z [PMID: 8410981]

Ligand id: 8893

Name: compound 5z [PMID: 8410981]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 98.19
Molecular weight 392.1
XLogP 1.45
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Compound 5z is cytotoxic in vitro and in vivo [1].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
DNA topoisomerase I Bt Inhibitor Inhibition 7.6 pIC50 - 1
pIC50 7.6 (IC50 2.7x10-8 M) [1]
Description: Inhibition of pBR322 DNA cleavage by calf thymus DNA topoisomerase I.