compound 5z [PMID: 8410981]

Ligand id: 8893

Name: compound 5z [PMID: 8410981]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 98.19
Molecular weight 392.1
XLogP 1.45
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Compound 5z is cytotoxic in vitro and in vivo [1].
Selectivity at bovine enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
DNA topoisomerase I Inhibitor Inhibition 7.6 pIC50 - 1
pIC50 7.6 (IC50 2.7x10-8 M) [1]
Description: Inhibition of pBR322 DNA cleavage by calf thymus DNA topoisomerase I.