BGB-283

Ligand id: 8958

Name: BGB-283

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 89.13
Molecular weight 478.13
XLogP 4.73
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Assay results provided in patent literature reports that BGB-283 inhibits mutant BRAFV600E with an IC50 value of 53nM and CRAF (RAF1) with an IC50 of 8.8nM [2]. The IC50 for BRAFV600E inhibition is reported as 23nM in [1].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
A-Raf proto-oncogene, serine/threonine kinase Inhibitor Inhibition 8.3 pIC50 - 1
pIC50 8.3 (IC50 5.6x10-9 M) [1]
B-Raf proto-oncogene, serine/threonine kinase Inhibitor Inhibition 7.5 pIC50 - 1
pIC50 7.5 (IC50 3.2x10-8 M) [1]
Description: Inhibition of wild type BRAF kinase domain (aa416-766)
Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
epidermal growth factor receptor Inhibitor Inhibition 7.5 pIC50 - 1
pIC50 7.5 (IC50 2.9x10-8 M) [1]
Description: Inhibition of wild type EGFR kinase domain (aa669-1210)