Ligand id: 8958

Name: lifirafenib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 89.13
Molecular weight 478.13
XLogP 4.73
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Tang Z, Yuan X, Du R, Cheung SH, Zhang G, Wei J, Zhao Y, Feng Y, Peng H, Zhang Y et al.. (2015)
BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers.
Mol. Cancer Ther., 14 (10): 2187-97. [PMID:26208524]
2. Zhou C, Wang S, Zhang G. (2013)
Fused tricyclic compounds as raf kinase inhibitors.
Patent number: WO 2013097224 A1. Assignee: Beigene, Ltd.. Priority date: 31/12/2011. Publication date: 04/07/2013.