Ligand id: 9056

Name: CP-601927

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 12.03
Molecular weight 227.09
XLogP 3.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Administration of CP-601927 potentiates the effects of sertraline and fluoxetine in mice.
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
nicotinic acetylcholine receptor α2 subunit Hs Agonist Partial agonist 8.9 pKi - 3
pKi 8.9 (Ki 1.2x10-9 M) [3]
Description: Measured against α2β4 nAchRs- species not identified.