CP-601927

Ligand id: 9056

Name: CP-601927

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 12.03
Molecular weight 227.09
XLogP 3.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Campion SN, Hurtt ME, Chatman LA, Cappon GD. (2011)
Toxicity study in juvenile rats with the α4β2 nicotinic acetylcholine receptor partial agonist CP-601,927.
Birth Defects Res. B Dev. Reprod. Toxicol.92 (4): 323-32. [PMID:21594972]
2. Fava M, Ramey T, Pickering E, Kinrys G, Boyer S, Altstiel L. (2015)
A randomized, double-blind, placebo-controlled phase 2 study of the augmentation of a nicotinic acetylcholine receptor partial agonist in depression: is there a relationship to leptin levels?.
J Clin Psychopharmacol35 (1): 51-6. [PMID:25422883]
3. Mineur YS, Einstein EB, Seymour PA, Coe JW, O'neill BT, Rollema H, Picciotto MR. (2011)
α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties.
Behav Pharmacol22 (4): 291-9. [PMID:21566524]