Ligand id: 9056

Name: CP-601927

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 12.03
Molecular weight 227.09
XLogP 3.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Campion SN, Hurtt ME, Chatman LA, Cappon GD. (2011)
Toxicity study in juvenile rats with the α4β2 nicotinic acetylcholine receptor partial agonist CP-601,927.
Birth Defects Res. B Dev. Reprod. Toxicol., 92 (4): 323-32. [PMID:21594972]
2. Fava M, Ramey T, Pickering E, Kinrys G, Boyer S, Altstiel L. (2015)
A randomized, double-blind, placebo-controlled phase 2 study of the augmentation of a nicotinic acetylcholine receptor partial agonist in depression: is there a relationship to leptin levels?.
J Clin Psychopharmacol, 35 (1): 51-6. [PMID:25422883]
3. Mineur YS, Einstein EB, Seymour PA, Coe JW, O'neill BT, Rollema H, Picciotto MR. (2011)
α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties.
Behav Pharmacol, 22 (4): 291-9. [PMID:21566524]