example 13 [WO2009109743]

Ligand id: 9077

Name: example 13 [WO2009109743]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 80.24
Molecular weight 347.14
XLogP 4.55
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Example 13 elicits a dose-dependent reduction in pain response in a rat model (the carrageenan induced thermal hyperalgesia model of inflammatory pain).
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Fatty acid amide hydrolase Hs Inhibitor Inhibition 7.4 pIC50 - 2
pIC50 7.4 (IC50 3.8x10-8 M) [2]