example 13 [WO2009109743]

Ligand id: 9077

Name: example 13 [WO2009109743]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 80.24
Molecular weight 347.14
XLogP 4.55
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Example 13 elicits a dose-dependent reduction in pain response in a rat model (the carrageenan induced thermal hyperalgesia model of inflammatory pain).
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Fatty acid amide hydrolase Inhibitor Inhibition 7.4 pIC50 - 2
pIC50 7.4 (IC50 3.8x10-8 M) [2]