defibrotide

Home
Ligands
defibrotide

GtoPdb Ligand ID: 9087

Synonyms: Defitelio®

defibrotide is an approved drug (EMA (2013), FDA (2016))

Compound class: Natural product or derivative

Comment: Defibrotide is a deoxyribonucleic acid derivative (single-stranded) purified from bovine lung. It has anticoagulant activity. Defibrotide is administered as defibrotide sodium. As this is a natural extract, its composition is not fully resolved, so no chemical structure is provided.

Summary
Biological activity
Clinical data
References

Bioactivity Comments
Defibrotide's anticoagulant action is much milder compared to the action of heparin and warfarin. It has a pleiotropic mechanisms of action with possibly multiple molecular targets so we have no affinity values [5] .

Bioactivity Comments

Defibrotide's anticoagulant action is much milder compared to the action of heparin and warfarin. It has a pleiotropic mechanisms of action with possibly multiple molecular targets so we have no affinity values [5] .