domagrozumab   Click here for help

GtoPdb Ligand ID: 9096

Synonyms: clone OGD1.0.0 [2] | PF-06252616 | PF06252616
Compound class: Antibody
Comment: Domagrozumab is a humanized monoclonal antibody targeting myostatin (MSTN), being investigated for potential therapeutic action in muscle wasting diseases.
Peptide sequences and structural information for this antibody are available from its IMGT/mAb-DB record. Protein BLAST analysis reveals 100% matches with sequences claimed in patent US8992913 [2].
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
myostatin Primary target of this compound Hs Antibody Binding 11.6 pKd - 2
⤷ pKd 11.6 (Kd 2.59x10-12 M) [2]