compound 74a [PMID: 27077528]

Ligand id: 9145

Name: compound 74a [PMID: 27077528]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 66.24
Molecular weight 326.2
XLogP 4.53
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Preclinical animal model studies indicate potential for compound 74a as a therapeutic for neuropathic pain and central pain [1].
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
TRPV3 Hs Antagonist Antagonist 6.4 pIC50 - 1
pIC50 6.4 (IC50 3.8x10-7 M) [1]