BMS-986122

Ligand id: 9157

Name: BMS-986122

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 80.29
Molecular weight 446.94
XLogP 4.31
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
BMS-986122 has little or no agonist activity alone. It dose dependently increases endomorphin-1 induced β-arrestin recruitment and inhibition of forskolin-induced adenyl cyclase activity and also potentiates DAMGO-stimulated GTPγS receptor binding [3].
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
μ receptor Allosteric modulator Positive 5.3 pKB - 3
pKB 5.3 (KB 5x10-6 M) [3]
μ receptor Allosteric modulator Positive 5.5 pEC50 - 3
pEC50 5.5 (EC50 3x10-6 M) [3]