Ligand id: 9256

Name: AZD8848

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 2
Rotatable bonds 17
Topological polar surface area 135.38
Molecular weight 569.33
XLogP 2.67
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Bioactivity Comments
Repeated intranasal TLR7 stimulation by AZD8848 reduces allergen responsiveness in allergic rhinitis [4]. We have been unable to find data to support the claim that AZD8848 is a selective TLR7 agonist, either in peer reviewed literature or patent documentation.