CDP840

Ligand id: 9330

Name: CDP840

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 31.35
Molecular weight 373.2
XLogP 8.29
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
In human asthmatic subjects oral CDP840 attenuated the late asthmatic response to allergen by 30% compared to placebo [1]. The treatment was well tolerated and showed no bronchodilatory or histamine antagonist effect.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
phosphodiesterase 4D Hs Inhibitor Inhibition 8.1 pKi - 3
pKi 8.1 (Ki 7.1x10-9 M) [3]
Description: Inhibition of [3H]-R-rolipram binding to recombinant human PDE4D3 isoenzyme
phosphodiesterase 4B Hs Inhibitor Inhibition 8.1 pKi - 3
pKi 8.1 (Ki 8.5x10-9 M) [3]
Description: Inhibition of [3H]-R-rolipram binding to recombinant human PDE4B2 isoenzyme
phosphodiesterase 4A Hs Inhibitor Inhibition 8.0 pKi - 3
pKi 8.0 (Ki 9.7x10-9 M) [3]
Description: Inhibition of [3H]-R-rolipram binding to recombinant human PDE-4 isoenzyme
phosphodiesterase 4C Hs Inhibitor Inhibition 7.7 pKi - 3
pKi 7.7 (Ki 1.89x10-8 M) [3]
Description: Inhibition of [3H]-R-rolipram binding to recombinant human PDE4C2 isoenzyme